Shionoyoshi New Crown Oral Drug Delivery Application! Japanese government to order 1 million servings

Japan’s Shionogi Pharmaceuticals develops oral medicines for the new coronary pneumonia (COVID-19), and has submitted an application to the Japanese government for a manufacturing and sales license in February, and has signed a basic agreement with the Japanese Ministry of Health, Labour and Welfare. 1 million people to provide oral medicine for the new crown for the treatment of mild patients.

Japanese Minister of Health, Labour and Welfare Shigeruyuki Goto said that the government has reached a consensus with Shionogi Pharmaceuticals and is waiting for the approval of the regulatory authorities. It is expected to purchase 1 million oral medicines. In the future, it will provide more treatment options for those diagnosed with mild symptoms, and in the future. After the delivery of 1 million doses of the drug, there is also a consensus that a certain amount will be continued to be purchased.

Shionogi Pharmaceutical has submitted an application to the Japanese government for a manufacturing and sales license on February 25, and is currently under review. If approved, it will become the first Japanese-made oral drug for the new crown, and it will be the first drug developed by Pfizer and Merck. Japan is the third antiviral drug approved for COVID-19.

Shionogi Pharma has global ambitions for new crown oral drugs, and with the support of the U.S. government, it is expected to start a Phase III clinical trial of new crown oral drugs worldwide, and it is expected to start a production line in April. , the target annual output provides more than 10 million servings.

Hong Kong PolyU develops compounds that can kill the new coronavirus, 3D-printed door handles help prevent epidemics

The Hong Kong Polytechnic University has successfully developed a material that can kill the COVID-19 virus. This material can be made into door handles, elevator buttons or antibacterial protective covers, which can kill almost all viruses and germs within 20 minutes.

Hong Kong TVB reported on the 13th that PolyU researchers first discovered compounds that can pierce virus cell membranes, such as positively charged cations, several years ago. A year and a half ago, the Department of Textiles and Clothing on campus led an interdisciplinary team to combine related compounds with resins to make translucent antibacterial films.

Studies have found that the film can kill almost all viruses and germs within 20 minutes, including COVID-19 virus, Staphylococcus aureus and Escherichia coli. The antibacterial film can kill 90% of viruses and bacteria within one year, and is effective within 3 years.

PolyU research teams have used 3D printing technology to make these antibacterial materials into door handles, elevator buttons or protective covers. The protective case costs about HK$20, and the elevator buttons are less than HK$10.

The report quoted Wen Xiaozhong, Dean of the Faculty of Engineering of PolyU, as saying that appliances made of these materials can be touched by people for several years, and have anti-toxic and anti-bacterial functions.

The research team has been invited by the Sham Shui Po Official Home Affairs Office to manufacture door handle sheaths for more than 100 unmanaged old residential buildings in the district to prevent the spread of the COVID-19 virus.

Pfizer and Moderna want to take the fourth shot, experts give three reasons: it is not necessary now

Thanks to the COVID-19 vaccine, the global epidemic has gradually slowed down and the economy has entered a stage of reopening. Opinions from all walks of life differ on whether the fourth dose of the vaccine is needed. Some experts believe that at present, the fourth dose of the vaccine is not the best epidemic prevention strategy, and three reasons are listed.

COVID-19 vaccine makers Pfizer and Moderna have filed with the U.S. Food and Drug Administration (FDA) for approval for a fourth dose of the vaccine for U.S. adults, Business Insider reported. In an interview with CBS over the weekend, Pfizer Chief Executive Albert Bourla said Americans should be prepared to get one dose of the COVID-19 vaccine every year, just as they get the flu shot every fall.

However, James Hildreth, senior advisor for the FDA’s COVID-19 vaccine, told Business Insider that he believes there is no need to rush a fourth dose of the vaccine at this stage, and gave three reasons to analyze the reasons:

The virus continues to mutate, but the new vaccine has not kept pace. The existing vaccines of Pfizer and Moderna are both developed based on the gene sequencing of the virus originating in Wuhan in January 2020, rather than targeting currently circulating COVID-19 variants (such as Omicron). ) and the Omicron subvariety BA.2.
There is currently no data to suggest that a fourth dose of the vaccine is necessary or helpful for most people. A study by the Centers for Disease Control and Prevention (CDC) showed that during the Omicron outbreak in early January this year, two doses of the vaccine were 88% effective in preventing severe illness and death, while three doses were 94% effective, reflecting injections After the 3rd shot, for most people there is only a small increase in results.


As things stand, the fourth shot of the vaccine has only marginal utility. An Israeli study of more than 1,000 health care workers showed that the fourth injection 4 months after the third dose did not significantly induce more immune responses, and the antibody concentration was only temporarily higher than the level after the third injection. back to the original.
A preliminary study published in January by the Sheba Medical Center, Israel’s largest hospital, found that after the fourth dose of the COVID-19 vaccine, the antibody concentration in the body increased, compared with the third dose. The concentration was higher, but still not enough to prevent infection with Omicron virus.

However, Sheba Medical Center still recommends a fourth dose of the vaccine for high-risk groups. The Israeli government announced in December 2021 that it will provide the fourth dose of COVID-19 vaccine to people over 60 years old, medical staff and immunocompromised people, making it the first country in the world to start the fourth dose of COVID-19 vaccine.

China and Hong Kong are the only ones in the world that are still pursuing “zeroing out”, and Taiwan still needs to spend a huge social cost to “eliminate the virus”?

Every winter, the green space of Frederiksberg Gardens in the Danish capital region is always firmly covered by thick ice and snow, becoming a vast outdoor ice skating rink; The ground passed by, without any cover on his face. This seemingly ordinary view is a long-lost freedom for Copenhagen residents.

On February 1, the Danish government determined that the new crown pneumonia is no longer a “socially critical disease”, and lifted most of the epidemic prevention measures, including wearing masks and showing vaccination certificates when entering public places, allowing people to return to normal life. Although there are still an average of 40,000 confirmed cases per day in Denmark, which has a population of less than 6 million, epidemiological experts believe that the relationship between infection and severe illness has been significantly “decoupled” and suggest that the government relax control and coexist with the virus.

Unbinding is not a maverick of the Nordic countries. Japan on the west coast of the Pacific Ocean immediately banned foreigners from entering the country after the first case of Omicron was imported from abroad at the end of November last year. This straightforward decision was overwhelmingly supported by 89% of the public at the time; however, on February 12, Japanese Prime Minister Kishida When Wenxiong inspected the airport’s epidemic prevention measures, he also announced that he hoped to think carefully in the direction of relaxing border control measures. European powers such as Britain, Germany, and France are also discussing how to gradually abolish epidemic prevention regulations.

Omicron’s Crisis and Opportunity
Looking at scientific data, Taiwan can follow up on deregulation
Taiwan, now, will also keep up with this wave of international unblocking. On February 14, Chen Shizhong, commander of the Central Epidemic Epidemic Center, officially announced at a regular press conference that the earliest time in mid-March will shorten the entry quarantine time for Chinese people from the current 14 days to 10 days; For foreign business people in Taiwan, the entry conditions will also be relaxed simultaneously, and the quarantine method will apply to the treatment of Chinese nationals.

On the eve of the announcement of the policy, Chen Shizhong explained in detail the ideological logic of the command center’s decision to de-regulate to Today Weekly. In his complete blueprint, all objective conditions are balanced, so that Taiwan is not only “able” to keep up with international trends, but also more important. What’s more, Taiwan “must” follow up.

“When Omicron first appeared, I saw both a crisis and a turnaround. The crisis was that the time from infection to infection was very short; the turnaround was that its severe and fatality rates were relatively low in the world.” Chen Shizhong It is true that the relaxation of control measures may indeed increase the number of confirmed cases in the country, but the command center is based on another consideration: “how to strike a balance between controlling the epidemic and maintaining economic activities”, and after a comprehensive assessment, it still makes an open policy. Decide.

“We can clearly see that the world will open its borders in the second half of the year. In that case, if Taiwan, a trading nation, continues to deny entry to business people, it will lose many opportunities and cause economic regression.” Chen Shizhong believes that refusing to open borders will This puts Taiwan’s industry at a disadvantage in competition with other countries.

“Zero” is no longer the point
It is the key to let the public know that vaccinations are the key to staying away from severe illness
Domestic epidemiological experts have a positive view on the stance of gradually relaxing the control, but they also call on the command center to proceed step by step, and buy time to prepare supporting measures before the relaxation. Vaccine coverage is the top priority.

Su Yiren, former director of the Centers for Disease Control and Prevention, pointed out that in the face of the epidemic, China and Hong Kong are almost the only ones in the world that are still pursuing “zero”, and Taiwan does not have to spend huge social and economic costs trying to “eliminate” the virus. However, he believes that the severe disease rate and mortality rate of the elderly over the age of 60 are much higher than those of the younger group. Among them, the protection of the elderly over the age of 75 who was the first to be vaccinated last year is even close to failure, and the command center should speed up to let the elderly Only when the coverage rate of the third dose of vaccine reaches more than 80%, the burden of medical resources caused by severe patients can be avoided.

According to statistics from the Centers for Disease Control and Prevention, as of February 14, 75.7% of Taiwanese people over the age of 12 received two complete doses of the vaccine, and the booster coverage rate was 30.6%. % and supplementary agents are 45.7%, which is still a long way from the open border standard assessed by experts.

In this regard, Chen Shizhong responded that the coverage rate of supplementary agents reached 50% of the population over the age of 12, which is an important supporting measure for opening the border. The command center hopes to reach the standard by mid-March.

Over the past two years, the new coronavirus has undergone several mutations, and human epidemic prevention measures have been continuously adjusted accordingly. Absolute blockade is obviously not a long-term solution. How to make good use of the tools at hand and the experience of fighting the virus, and carefully strike a balance between the risk of infection and normal life, is a long-term issue that Taiwan and the world must face.

Yahoo Japan lets employees work remotely

Yahoo Japan originally planned to bring employees back to the office this year, but the policy took a major turn, saying in January that it would allow employees to work remotely and pay for transportation to the office at any time, including by plane.

Yahoo Japan has been promoting remote work. In 2014, it established a remote work system for working from anywhere. Before the epidemic, the number of working days at home was limited to 5 days per month, and the implementation was expanded after the epidemic. At a time when Japanese companies began to call their employees back to the office in the second half of last year, up to 90% of Yahoo Japan’s employees were allowed to work remotely as of January.

Yahoo Japan’s latest rules allow employees to work remotely permanently, but must live within commuting distance of the office, and if instructed to enter the office 24 hours in advance, employees must arrive by 11 a.m. the next day. The way to arrive can be by high-speed rail or by plane. The maximum monthly allowance is 150,000 yen, which is about NT$36,000, the daily allowance is limited to 88 US dollars, and the single commute cost is limited to 56 US dollars. The company also encourages face-to-face communication in a more pleasant way, subsidizing 5,000 yen per employee per month for social gatherings.

According to Yahoo Japan President Kentaro Kawabe, 90% of employees are still working remotely, and most employees say that remote work is no different or better than in the office, so Yahoo employees are allowed to live anywhere in Japan, but He also emphasized that this does not mean denying the benefits of the office, so the company allows employees to “fly” in when they need it.

A Yahoo employee told Japanese media that working remotely has enabled him to move closer to his family and now lives in a resort town, about a 90-minute bullet train ride from Tokyo.

Yahoo Japan, a subsidiary of SoftBank Group’s Z Holdings, currently employs 8,000 people. Scheduled to go into effect on April 1. Rival Japanese e-commerce company Mercari last September also let employees work from anywhere.

A survey of nearly 10,000 companies in Japan found that the work-from-home rate in Japan peaked at around 55% in the early months of the COVID-19 pandemic, falling to around 38% by March 2021. The 2022 Omicron outbreak has the Japanese government aggressively pushing businesses to embrace remote work.

In response to the epidemic and the shortage of IT talents, the Minister of Economic Promotion of Japan recently called on the three major business lobby groups to propose plans for remote working and actively promote the remote working system. Panasonic has announced plans for a four-day workweek, and Mizuho Financial Group has implemented a four-day workweek. Japan’s Mazda (MAZDA) reduced the proportion of office staff to less than 30%. NTT said last September that it would allow employees to work remotely in principle, with a goal of making remote work standard work by 2025. Nearly half of NTT Japan’s approximately 180,000 employees work remotely.

Remote work is here to stay after the pandemic. Marc Cenedella, chief executive of Ladders, a high-level human resources firm, said the shift to remote work would be the biggest social change since the end of World War II.

Sweden declares outbreak over

The Swedish media quoted Health and Social Affairs Minister Lena Hallengren as saying on February 9 that the new coronavirus pneumonia (COVID-19) epidemic is over.

“I would say this pandemic is over as we know it,” Hallengren told the Dagens Nyheter. As far as it is concerned, it is (closed)”.

After Denmark became the first country to lift all epidemic prevention restrictions, Sweden also lifted almost all but a few epidemic prevention bans on the 9th and stopped most testing measures. Local pubs and restaurants can open until 11pm with no limit on the number of people, and restrictions on large indoor gatherings and the use of vaccine passes have been lifted.

Canadian Prime Minister Justin Trudeau tests positive for coronavirus

Canadian Prime Minister Justin Trudeau tweeted on Jan. 31 that he had tested positive for the novel coronavirus pneumonia (COVID-19) virus.

Canadian PM Trudeau, family moved to 'secret location' as anti-vax protest  flares up: Report - World News

This morning I tested positive for the new coronavirus pneumonia virus,” he tweeted. I feel good – I will continue to work remotely this week while following public health guidelines. Everyone, please get vaccinated and get a booster dose.

Trudeau said he has self-isolated since one of his children tested positive. He said he will continue to isolate and work remotely while he recovers.

He has received two doses of Newcastle pneumonia in 2021 and a booster dose at a pharmacy in Ottawa in early January.

Although he was diagnosed with the disease, he will hold a press conference to speak about the protesters who have blocked some roads in Ottawa.

Doomsday clock counts down 100 seconds, scientists warn: 2022 is no safer than two years ago

The Doomsday Clock, which represents top scientists and security experts’ judgments on the dangers of human existence, has remained in a very dangerous position 100 seconds before midnight this year, including that the progress of a COVID-19 vaccine has been offset by increasing misinformation and other threats. Rachel Bronson, chief executive of the Bulletin of the Atomic Scientists, announced today that the world is no safer this year than it was two years ago, when the Doomsday Clock was set to 100 seconds to midnight . She told reporters at the 75th anniversary of the establishment of the Doomsday Clock: “If humanity is to avoid an existential catastrophe, a catastrophe more severe than it has ever seen before, national leaders must do their best to combat misinformation, focus on science and cooperate. better.”

Doomsday Clock remains perilously close to midnight – Physics World

The group said in its full statement that the fact that the hand of the doomsday clock has not moved closer to midnight does not mean the threat has stabilized. “On the contrary, the Doomsday Clock is still the closest to the end of civilization, because the world is still at an extremely dangerous moment,” said Bronson. The Bulletin of the Atomic Scientists was published in 1945 by Manhattan Project scientists involved in the development of nuclear weapons. , such as Albert Einstein (Albert Einstein), Oppenheimer (J Robert Oppenheimer) and others created. They then introduced the Doomsday Clock in 1947, a symbol of global vulnerability to catastrophe. The clock’s time is determined by the organization’s committee, with input from a sponsoring committee that includes 11 Nobel laureates.

In its statement, the Bulletin of the Atomic Scientists noted promising developments in early 2021, including the re-signature of the New Strategic Arms Reduction Treaty (New START) between the United States and Russia. But international tensions continue to mount, including the recent Ukraine crisis and the continued development of hypersonic weapons by the United States, Russia and China. The Bulletin of the Atomic Scientists stated that “as the riots at the U.S. Capitol on January 6, 2021 proved,” no country is immune to the various threats posed to democracy. More than 10 percent of those charged in the incident were active or retired military personnel, underscoring extremism in the military.

Doomsday Clock' stuck at 100 seconds to midnight

While the world’s scientific community is focusing on COVID-19 (coronavirus disease 2019), governments must prepare for other biological threats, ranging from weapons programs to rising antibiotic resistance, the group sees within the next 10 years. , antibiotic resistance could spark a new global pandemic.

Novak Djokovic is banned from entering Australia for the next 3 years, and he can apply for an exemption under one condition

Novak was escorted from Melbourne Airport by two government officials in black on the night of the judge’s sentencing on the 16th. The British media “BBC” reported that on the flight tracking website “FlightRadar24”, its destination was Dubai in the Middle East, and it is expected to transfer to Spain, Monaco or hometown Serbia

.

Novak’s visa turmoil has come to an end, and another key question is whether the nine-time Australian Open champion will be banned from Australia for three years?

Immigration Minister Alex Hawke revoked Novak’s visa under Section 133C(3) of the Immigration Act. According to the law, he cannot obtain a visa for three years, which means he will not be able to participate in the next three Australian Opens.

However, this law also contains amnesty clauses. “BBC” quoted a TV interview with former Australian immigration officer Abul Rizvi, pointing out that if the person whose visa is revoked is in the interests of Australia’s national interests, or the interests of domestic citizens and permanent residents, there is a chance Request a visa waiver from the Australian government.

Abul Rizvi said: “Novak can also use Compassionate and Compelling to apply for a visa waiver to the Australian government, which I think he will do if he wants to play next year’s Australian Open. I guess whoever the minister is will accept it. “He thinks there will be less resistance to Novak if the outbreak in Australia eases next year.

American runner’s exaggerated feat, 95 days of running the marathon in a row to break the record, still challenge the goal and fail

It is very common for runners to challenge the marathon, but the feat of running 95 marathons on the 95th is the only one who can do it.

American cross-country runner Alyssa Clark ran a marathon for 95 consecutive days last year and recently received a Guinness World Records certificate confirming that she is the only one in the world.

Everything stems from the new crown pneumonia.

Clark, who lives in Italy with her husband, started this long marathon in March 2020, but at first she did not have the ambition to set a record, nor did she have the concept of breaking a record.

At that time, the epidemic shrouded Europe, and Clark, who was forced to isolate at home, was like you and me, staying at home either eating or watching TV. But running is her daily routine, and she insists on running the full distance on the treadmill every day. On the 30th day, a friend told her that she was close to half of the world record.

“The original record was 61 days,” Clark finally had some idea of ​​the record, and aimed to break the record. On the 61st day, the road to her plan was rocky, when her husband was transferred back to the United States because of his service in the Navy. At that time, due to the impact of the epidemic, there were not many commercial flights out of Italy, so the couple took a military cargo ship to Germany to transfer. In order not to break the cable of the challenge, Clark immediately found the treadmill and completed 42.195 kilometers as soon as the boat berthed to the dock.

Unexpectedly, on day 75, Clark began to tire of the challenge and set a goal of 100 days. On the 96th day, she finally encountered the biggest obstacle. That day, she ran as usual, but when she ran 12 kilometers, she had chest pain and coughing and discomfort. After being sent to the hospital for examination, it was confirmed that both she and her husband were infected with new coronary pneumonia, and the challenge was terminated.

“95 marathons in 95 days, spanning 3 countries. Run in the heat of nearly 38 degrees, in the early morning, on a treadmill alone, and with my best friend, and I’ll always remember that But, it’s time to stop. It’s become almost a part of my daily life, and with so much disruption to daily life in the midst of the Covid-19 pandemic, I think the marathon has really given me a purpose for the day,” Clark said. .

The record stays at 95 days, and everything finally has new coronary pneumonia.